The Basic Detector Module (BDM) | PET Detector Module by X-Z LAB is all-digital, providing high-precision information of incoming gamma photons. Its modular design allows it to be set up with various PET systems, including PET/CT and PET/MRI. Preview its capabilities in the video below:
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Combined PET-MR: A Technology Becomes Mature
Researchers examine the use of combined PET/MR in their study published in the Journal of Nuclear Medicine run by the Society of Nuclear Medicine and Molecular Imaging (SNMMI). With breakthroughs in finding new detectors to replace photomultiplier tubes (PMT) in traditional PET, such as avalanche photodiodes (APD), Geiger-mode APDs (AKA silicon PMTs or solid-state PMTs), and silicon photomultipliers (SiPM), tolerance to magnetic fields and time-of-flight PET scans became possible. X-Z LAB’s Basic Detector Module (BDM) | PET Detector Module utilizes this technology and enhances it with our patented multi-voltage threshold (MVT) algorithm. Although the researchers do not see combined PET/MR
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Advantages of Scanning Primates vs. Mice
Dr. Catharine Paddock’s article for Medical News Today, “PET scans can help select best TB drugs for trials,” reveals advantages of scanning primates versus mice due to similar disease profiles shared by human and primate. In a study led by the University of Pittsburgh School of Medicine, linezolid, a drug developed to treat extensively drug-resisistant tuberculosis (XDR-TB), was found to be effective in humans and macaques using PET/CT scans, although earlier studies on mice showed no effect. X-Z LAB’s small animal PET technology allows small animals as well as not-so-small animals to be scanned, thereby improving the preclinical process. The Trans-PET® BioCaliburn® occupies this niche
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PET Advantages in Oncology
President of Radiological Technologies Universities, Brent D. Murphy, MS, DABR, underscores the efficacy of PET and champions increased utilization of PET in oncology. In the linked presentation, Dr. Murphy illustrates PET advantages in both sensitivity (the probability of a positive test, given that a patient is ill) and specificity (the probability of a negative test, given that a patient is well). The improvements discussed can apply to small-animal PET and preclinical scans, like the Trans-PET® BioCaliburn®. Download PDF
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Performance Evaluation of the Trans-PET® BioCaliburn® LH System
Abstract The Trans-PET® BioCaliburn® LH is a commercial positron emission tomography (PET) system for animal imaging. The system offers a large transaxial field-of-view (FOV) of 13.0 cm to allow imaging of multiple rodents or larger animals. This paper evaluates and reports the performance characteristics of this system. Methods: in this paper, the system was evaluated for its spatial resolutions, sensitivity, scatter fraction, count rate performance and image quality in accordance with the National Electrical Manufacturers Association (NEMA) NU-4 2008 specification with modifications. Phantoms and animals not specified in the NEMA specification were also scanned to provide further demonstration of its
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Development of PET
A Simple All-digital PET System
Abstract Positron emission tomography (PET) systems employ mixed-signal front-end to carry out relatively simple, and ad hoc , processing of the charge pulses generated upon event detection. To obtain, and maintain over time, proper calibrations of the mixed-signal circuitry for generating accurate event information is a challenging task due to the simplicity of the event processing, and the huge number of channels and multiplexing of the input signals found in modern PET systems. It is also difficult to modify or extend the event-processing technologies when needs arise because it would involve making changes to the circuitry. These limitations can be
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A Multi-threshold Sampling Method for TOF-PET Signal Processing
Abstract As an approach to realizing all-digital data acquisition for Positron Emission Tomography (PET), we have previously proposed and studied a multi-threshold sampling method to generate samples of a PET event waveform with respect to a few user-defined amplitudes. In this sampling scheme, one can extract both the energy and timing information for an event. In this paper, we report our prototype implementation of this sampling method and the performance results obtained with this prototype. The prototype consists of two multi-threshold discriminator boards and a time-to-digital converter (TDC) board. Each of the multi-threshold discriminator boards takes one input and provides
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